How CJC 1295 Works

Now that you understand what CJC 1295 is (a peptide) and where it came from, it’s now time to look at precisely how it fulfils its function within the body by studying its exact mechanism of action.

How CJC 1295 Amplifies GH Production

If you know anything about GHRP (Growth Hormone Releasing Peptide) products, then the following mechanism of action is going to be incredibly familiar to you.

In many ways, CJC 1295 mimics the effects on offer when utilising GHRP 6 or 2 (or any of the other popular peptide varieties that form part of that particular niche) though it “cuts out” the elements associated with ghrelin, and instead picks up from the part of the gh release process where GHRH is released by the hypothalamus.

Ordinarily, the hunger hormone ghrelin would kick start this growth hormone release process.

Ghrelin releases as a means of serving two purposes; it both tells the body that we need to ingest nutrients (via food) and simultaneously triggers the release of growth hormone so that we can capitalise on them / use them to “evolve.”

You’ll find a more in depth explanation of this process on any one of the GHRP product profiles, but what it’s important to understand is that ghrelin sends a signal to the hypothalamus of the brain to trigger the release of growth hormone releasing hormone.

Once released, growth hormone releasing hormone then travels to the somatotropic cells (these cells serve as growth hormone storage “chambers” of sorts) and triggers them to release their stores of growth hormone.

It’s this latter aspect (the stimulation of the somatotropic cells) that CJC 1295 fulfills when it enters the body. GHRP products serve as ghrelin mimetics, but GHRH products like CJC 1295 serve as GHRH mimetics.

This means that they directly emulate the function of growth hormone releasing hormone by manipulating the somatotropic cells into releasing growth hormone.

This is where things get slightly more complex though; the powerful “pulse” initiated by growth hormone releasing peptides isn’t present when integrating CJC 1295 or any other growth hormone releasing hormone variety.

Instead, CJC 1295 “gently” elevates blood plasma levels of growth hormone rather than delivering a high-impact surge. Further to this (and as previously outlined) it does not inhibit the effects of somatostatin.

This study (one of the rare human studies) concludes that “normal” pulsation was not altered throughout the course of CJC 1295 administration, though blood growth hormone levels were increased.

This is why GHRH products notoriously cannot be optimally integrated for anabolic purposes unless they are combined or timed with a growth hormone pulse.

If you combine this lack of a powerful pulse with a lack of ability to diminish the effects of somatostatin; you’re left with a compound that is realistically going to be marginally useful at best, in theory.

This is where we must also consider the other passive benefits on offer with even a modest increase in GH levels; namely the enhancement of IGF-1 levels and what that may lead to for the user.

The Bodies IGF-1 System Explained

This is where the effects of CJC 1295 may prove to be beneficial in their own right, even without the use of a GHRP compound.

When people look at GHRH products in general, they often concern themselves almost exclusively with how much GH these items are capable of releasing; rare are the people who consider what these items can do to promote IGF-1 release though.

This is a tremendously flawed thought process though, being that IGF-1 is arguably the primary reason why anyone would choose to supplement with exogenous growth hormone products in the first place (at least those who wish to develop their aesthetics.)

This is because it isn’t actually growth hormone itself that triggers anabolism – it’s the release of IGF-1 that ultimately leads to muscle growth / lean tissue repair taking place.

IGF-1 stands for Insulin like Growth Factor 1. When growth hormone is released into the bloodstream, it then signals the liver to release this all important anabolic element.

The reason why you should take interest in IGF-1 is because of the manner in which it “splits” into two following periods of intense physical exercise.

When it splits, two IGF-1 substrands are created. These substrands are known as IGF-IEa and IGF-IEb. IGF-1 IEa is also known as Mechano Growth Factor (MGF).

Mechano growth factor recruits satellite muscle cells into the growth and repair process – this means that this element of IGF-1 alone plays a crucial role in the aesthetic development of the human body.

Considering then, that growth hormone levels will be elevated and subsequently so too will IGF-1 levels, it’s safe to say that isolated CJC 1295 use does hold some merit.

Another factor to consider is that of IGF-1’s structure in regards to its effects on insulin receptors. As it’s name implies, IGF-1 resembles insulin very closely on a molecular level.

It resembles it so closely in fact that it can actually bind to the insulin receptors (although it cannot do this with the same efficiency that insulin itself can.)

The reason why this matters is because insulin is needed to effectively transport glycogen (from carbohydrates) throughout the bloodstream – should it be unable to bind to its receptors, this means that the body is unable to access glycogen as its primary source of fuel.

As such, it must instead turn to fat under these unique circumstances. This actually means that enhanced levels of IGF-1 are crucial for accelerating lipolysis (fat burning.)

Combined, the effects of IGF-1 will see the CJC 1295 user improve their anabolic capacity whilst reducing body fat – though it must still be stated that the degree to which they can achieve this end result will be diminished through somatostatin being able to exert its effects.

This is because the higher the level of freely available growth hormone in the body, the higher the level of IGF-1 as a result.

With minimal growth hormone elevation (due to inhibition by somatostatin) one can only expect to achieve so much in regards to the previously mentioned outcomes, if anything measurable at all.

The Advantages Of CJC 1295 Over HGH Administrations

Though GHRH is a growth hormone secretagogue, it differs dramatically from synthesised human growth hormone (humatrope, genotropin etc.)

This is because of the manner in which GHRH fulfils its “purpose” when compared to human growth hormone – the former works with the body’s natural processes whereas the latter introduces an exogenous surge of “false” human growth hormone to “top up” the body’s existing levels.

When comparing CJC 1295 to human growth hormone in terms of efficiency on a like for like basis, there is truly no comparison whatsoever between the two; human growth hormone hands down beats CJC 1295 on every level in terms of potency (though CJC would certainly score extra points for “safety” due to it promoting “organic” growth hormone production.)

It would be tremendously unfair to make this comparison though, and instead CJC 1295 being used in conjunction with a growth hormone releasing peptide like GHRP 6 would be the only appropriate means of us putting it to the test against hgh.

When taking this product combination into account, there are merits to implementing either compound type. We will now assess the benefits of hgh before comparing them with the GHRP / GHRH combination.

HGH benefits include:

  • More growth hormone introduced into the body with each dose compared to secretagogues
  • Potentially increased anabolic capacity / fat burning compared to secretagogues as a result of enhanced gh levels
  • Potentially better for recovery owing to the higher concentration of gh introduction

You’ll find on the whole, that the hgh benefits largely revolve around it being “stronger” than the secretagogue combination. As you’ll no doubt be aware by now though, “stronger” almost always dictates a higher risk factor by default.

In this instance, this risk comes in the form of an elevated side effect potential in conjunction with desensitization to growth hormone as a result of it being exogenously “forced” into the body at high levels.

It’s also worth noting that any adverse issues would stand to manifest to a more potent degree owing to the higher strength of hgh too; should you be sensitive to secretagogues, it probably goes without saying that moving onto hgh would not be particularly wise.

On balance, the merits of the growth hormone secretagogue combination are:

  • This product combination works with and utilises the body’s “organic” resources to produce gh, meaning that desensitization is either less severe or does not occur at all depending on which GHRP product is used
  • In conjunction with an effective nutrition and training plan, there is little reason why most people wouldn’t be able to achieve their goals using a secretagogue combination, potentially making hgh unnecessary
  • The cost of HGH compared to secretagogues is tremendously elevated – this makes the latter not only a viable alternative, but a financially beneficial alternative too
  • Arguably, secretagogues are easier to “control” owing to their short half-life within the body (an exception is of course CJC 1295 with added DAC, but as discussed the presence of somatostatin may help to counteract any concern in regards to gh bleed and even elevated levels outside of the body’s pulse windows)

Overall, what you lack in strength you will gain in terms of “selectability” and diminished risk / cost. You could say that the manner in which secretagogues work with the body is the way that the body would “prefer” to access growth hormone, rather than having it forcibly introduced.

It’s important to remember either way though that regardless of your product choice; you are still forcing a mechanism of action or substance upon the body that would not normally occur or be present at the time of its integration.

In short – making the decision based on whether or not you wish to avoid creating internal “stress” may be somewhat fruitless being that neither method of amplifying growth hormone is entirely “natural”. They both create excess internal demands where a demand would not have existed otherwise.

This last statement in particular may be a struggle for some people to come to terms with owing to the fact that many swear by the minimal risk of side effects associated with secretagogues, but this is sadly the truth of pharmaceutical compounds in general.

Low risk does not by default dictate that the body is not being placed under excess strain – this could even be said for the likes of cold medicine or painkillers. The body has to perform processes when they are present that would not ordinarily be occurring.

In the case of a growth hormone secretagogue (be it GHRH or GHRP) – it’s safe to say that these added “processes” are going to be elevated in comparison to those associated with “digesting” over the counter medication.

As such, you should not take one product or the other (in this scenario) in the hope that no extra strain on the body whatsoever will be produced, rather; make your choice based on your individual requirements and whether or not you wish to run the higher risk of adverse issues arising through taking hgh.

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